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Zest Health Guide to Bimzlex

(bimekizumab-bkzx)
What is Bimzlex and how does it work?

Bimzlex is a biologic injection that targets IL-17, a pro-inflammatory signal of your immune system that causes psoriasis. By calming this overactive response, Bimzlex helps reduce redness, plaque development and pain in your skin and joints.

How do I take Bimzlex?

Your Zest team will customize your care based on your goals and how your body responds. Here’s what to expect:

Getting started

To get ready and ensure this treatment is safe and effective you’ll need to complete the following:

  • Submit baseline photos for your skin severity assessment.
  • Complete laboratory screening: tuberculosis and metabolic function screening.
  • Provide previous treatment records, if requested.
Dosing Schedule
Loading Dose
Maintenance Dose
Dose reduction1
Scheduled treatment break2

1 injection at week 0, 4, 8, 12 and 16

1 injection every 8 weeks

1 injection every 16 weeks

Up to 7-8 months on average

1 Considered after 16 weeks of treatment.

2 Gordon et al. The Lancet, 2021.

Results to expect
  • Many people notice less itching and fewer joint symptoms as early as 4 weeks.
  • By 16 weeks,  9 in 10 people had 90% clearer skin!3

3 Bimzelx.com – “Why Bimzelx: Results”.

Can I reduce my doses over time?

Yes! Once your symptoms are under control, your Zest dermatology provider will work with you to create a long-term plan. This might include stretching out injection intervals or taking planned medication breaks when appropriate.

Is it safe? Are there side effects?

Most side effects are mild and may improve with time. These can include:

  • Redness or swelling at the injection site
  • Upper respiratory and oral yeast infections
  • Headaches
  • Diarrhea
Important reminders

To get ready and ensure this treatment is safe and effective you’ll need to complete the following:

  • Submit baseline photos for your skin severity assessment.
  • Complete laboratory screening: tuberculosis and metabolic function screening.
  • Provide previous treatment records, if requested.
Can I afford it?

We know affordability is important! While Bimzlex can cost between $32,000-$40,000 a year without insurance, many government and commercial plans cover it. 

Your Zest team will help you navigate insurance, co-pay programs, and assistance options to make it as affordable as possible.  In addition, we ensure you only take the necessary amount of medication to meet your skin health needs.

When to contact your Zest Team

Reach out to us if you:

  • Have severe allergic reactions or infections
  • Are diagnosed with IBD or develop unexpected GI symptoms
Have more questions?

Contact your Zest care team by texting (865)-426-1746 or sending a chat message from your portal. You’ve got this, and we’ve got you. Together, let’s work toward relief and clear skin!

BIMZLEX is a registered trademark of UCB Biopharma SRL.

Third party trademarks used herein are trademarks of their respective owners.

Last updated: April 2025

Zest Health - Bimzlex Dose Reduction

(bimekizumab-bkzx)
What is Bimzlex and how does dose reduction work?
Am I a candidate for dose reduction?
Reduced Dosing Schedule
Standard dose
Step 1 dose reduction
Step 2 dose reduction
Scheduled treatment break1

What to expect
What are the benefits of dose reduction?
Are there risks to dose reduction?
Have more questions?

Contact your Zest care team by texting (865)-426-1746 or sending a chat message from your portal. You’ve got this, and we’ve got you. Together, let’s work toward relief and clear skin!