Zest Health Guide to Biosimilar Humira

(Adalimumab)
What is Biosimilar Humira and how does it work?

Biosimilar Humira is a generic form of the biologic Humira, an injection that targets TNF-alpha, an inflammatory signal of your immune system that causes psoriasis. By calming this overactive response it helps reduce redness, plaque development and pain in your skin and joints.

How do I take Biosimilar Humira?

Your Zest team will customize your care based on your goals and how your body responds. 

Here’s what to expect:

Getting started

To get ready and ensure this treatment is safe and effective you’ll need to complete the following:

  • Submit baseline photos for your skin severity assessment
  • Complete baseline bloodwork, if indicated
  • Provide previous treatment records, if requested
Dosing Schedule
Loading Dose
Maintenance Dose
Dose reduction1
Scheduled treatment break2

2 injections

1 injection every 2 weeks

1 injection every 4 weeks

An average of 4 months off injections

Loading Dose
Starting Dose
Maintenance Dose

2 injections

1 injection every 2 weeks

1Considered after 16 weeks of treatment.

2Based on results in Humira® 2 Wang et al. Chin Med J, 2020.

Expected results
  • Many people notice less itching and fewer joint symptoms as early as 4 weeks.
  • By 16 weeks, 75% of people have clearer or nearly clear skin!3

3Based on results in Humira®. Humira.com – “Psoriasis”. Accessed on May 12, 2025.

Can I reduce my dose over time?

Yes! Once your symptoms are under control, your Zest dermatology provider will work with you to create a long-term plan. This might include stretching out injection intervals or taking planned medication breaks when appropriate.

Is it safe? Are there side effects?

Most side effects are mild and can include:

  • Redness or swelling at the injection site
  • Cold-like symptoms or mild headaches
  • Nausea 
  • Elevated liver enzymes
When to contact your Zest Team

Reach out to Zest if you:

  • Develop allergic reactions or infections
  • Notice unusual joint pain, vision changes, or unexpected symptoms
Have more questions?

Contact your Zest care team by texting (865)-426-1746 or sending a chat message from your portal. You’ve got this, and we’ve got you. Together, let’s work toward relief and clear skin!

HUMIRA is a registered trademark of AbbVie Biotechnology Ltd.

Third party trademarks used herein are trademarks of their respective owners.

Last updated: November 2025

Zest Health - Biosimilar Humira Dose Reduction

(Adalimumab)
What is Biosimilar Humira and how does dose reduction work?
Am I a candidate for dose reduction?
Reduced Dosing Schedule
Standard dose
Step 1 dose reduction
Step 2 dose reduction
Scheduled treatment break1

What to expect
What are the benefits of dose reduction?
Are there risks to dose reduction?
Have more questions?

Contact your Zest care team by texting (865)-426-1746 or sending a chat message from your portal. You’ve got this, and we’ve got you. Together, let’s work toward relief and clear skin!