Zest Health Guide to Taltz

(Ixekizumab)
What is Taltz and how does it work?

Taltz is a biologic injection that targets IL-17, an inflammatory signal of your immune system that causes psoriasis. By calming this overactive response, Taltz helps reduce redness, plaque development and pain in your skin and joints.

How do I take Taltz?

Your Zest team will customize your care based on your goals and how your body responds. 

Here’s what to expect:

Getting started

To get ready and ensure this treatment is safe and effective you’ll need to complete the following:

  • Submit baseline photos for your skin severity assessment
  • Complete baseline bloodwork, if indicated
  • Provide previous treatment records, if requested
Dosing Schedule
Loading Dose
Maintenance Dose
Dose reduction1
Scheduled treatment break2

2 injections to start, then 1 injection every 2 weeks for 12 weeks

1 injection every 4 weeks

1 injection every 8 weeks

An average of 5 months off injections

Loading Dose
Starting Dose
Maintenance Dose

2 injections to start, then 1 injection every 2 weeks for 12 weeks

1 injection every 4 weeks

1Considered after 16 weeks of treatment.

2Papp et al. Acta Derm Venerol, 2022.

Expected results
  •  Many people notice less itching and fewer joint symptoms as early as 2-4 weeks.
  • By 12 weeks, 90% of people saw improvement in their skin!3

3Taltz – Plaque Psoriasis. taltz.lilly.com. Accessed on April 17, 2025.

Can I reduce my dose over time?

Yes! Once your symptoms are under control, your Zest dermatology provider will work with you to create a long-term plan. This might include stretching out injection intervals or taking planned medication breaks when appropriate.

Is it safe? Are there side effects?

Most side effects are mild and can include:

  • Redness or swelling at the injection site
  • Upper respiratory and oral yeast infections
  • Cold-like symptoms or mild headaches
  • Nausea or fatigue
When to contact your Zest Team

Reach out to Zest if you:

  • Develop allergic reactions or infections
  • Notice unusual joint pain, vision changes, or unexpected symptoms
Have more questions?

Contact your Zest care team by texting (865)-426-1746 or sending a chat message from your portal. You’ve got this, and we’ve got you. Together, let’s work toward relief and clear skin!

TALTZ is a registered trademark of Eli Lilly and Company.

Third party trademarks used herein are trademarks of their respective owners.

Last updated: November 2025

Zest Health - Taltz Dose Reduction

(Ixekizumab)
What is Taltz and how does dose reduction work?
Am I a candidate for dose reduction?
Reduced Dosing Schedule
Standard dose
Step 1 dose reduction
Step 2 dose reduction
Scheduled treatment break1

What to expect
What are the benefits of dose reduction?
Are there risks to dose reduction?
Have more questions?

Contact your Zest care team by texting (865)-426-1746 or sending a chat message from your portal. You’ve got this, and we’ve got you. Together, let’s work toward relief and clear skin!