Everything You’ve Wanted to Ask About Biologics

Biologic medications have transformed what’s possible in dermatology. For many people living with psoriasis or eczema, these therapies bring long-lasting relief, fewer flares, and healthier skin with fewer daily medications.

Still, it’s normal to have questions—especially if you’ve been newly prescribed a biologic or are considering one for the first time. Below, we answer some of the most common questions patients ask to help you feel informed and confident on your treatment journey.

What Is a Biologic?

Biologics are medications made from living cells that work by targeting the specific immune pathways responsible for inflammation in the skin. Unlike traditional oral medications that affect your entire immune system, biologics are more precise, calming only the overactive signals that drive your condition.

They’re usually given as an injection under the skin—some in a clinic, others at home after you’ve been trained by your care team.

How Safe Are Biologics?

Biologics have been studied for decades and are among the most well-monitored medicines available today. Before approval, each biologic goes through extensive clinical trials and continues to be tracked closely for safety once used in real-world care.

Like all medications, biologics can cause side effects—but serious complications are rare. The most common issues patients experience are injection site reactions (such as mild redness, swelling, or soreness where the medication is given) and infections, since biologics slightly adjust how the immune system functions.

At Zest, your care team keeps a close eye on these potential effects through regular check-ins and lab monitoring where indicated. Because we follow your progress over time, we can recognize when your skin is stable enough to reduce treatment frequency or dosage, helping lower the chance of side effects while maintaining clear, healthy skin.

How Long Do Biologics Take to Work?

Most people begin noticing improvement in 6 to 8 weeks, though some see results sooner. It can take up to three months for full benefit. Staying consistent and following your care plan helps your skin stabilize faster and stay clear longer.

Do I Have to Stay on a Biologic Forever?

No. Biologics aren’t meant to be lifelong for everyone. Once your skin is clear and stable, it’s often possible to adjust how often you take your medication—or even take a planned break under close supervision.

This is called “as-needed” dosing—using your biologic only when your skin shows signs of activity, rather than staying on a fixed schedule indefinitely. For many patients, this approach helps maintain control while reducing unnecessary medication exposure and side effects.

At Zest, we look beyond your prescriptions to understand the root cause of your inflammation—from stress and sleep to nutrition and overall health. By addressing these underlying factors, we can often reduce your reliance on medication while keeping your skin clear and your confidence high. Your Zest care team monitors your progress closely and helps determine when it’s the right time to step down, so your treatment always fits your skin’s needs and your life.

Can Biologics Be Combined With Other Treatments?

Yes. Biologics are highly effective, but they should never be the only part of your care plan. Managing chronic skin conditions like psoriasis and eczema often requires a combination of approaches—targeting not just inflammation, but the underlying factors that contribute to it.

In traditional dermatology settings, care often centers on prescriptions and short check-ins. At Zest, we take a broader view. Your treatment plan may include topical medications, light therapy, and lifestyle-based strategies such as stress management, sleep support, or nutrition coaching—all designed to complement your biologic and strengthen results.

What Monitoring Is Needed While on a Biologic?

Before starting, your care team will review your health history and complete any necessary baseline testing to make sure the medication is right for you. After that, staying on track is simple.

With Zest’s virtual, high-access care, follow-ups fit easily into your routine—you can check in from home, share updates through your portal, or message your provider anytime. These quick touchpoints help your team celebrate progress, answer questions early, and keep your treatment working smoothly without disrupting your day.

Can I Get Pregnant or Breastfeed While on a Biologic?

If you’re planning a pregnancy, currently pregnant, or breastfeeding, let your Zest care team know. This is an ideal time to re-evaluate your treatment goals and prioritize safety for both you and your baby. Together, we’ll review the most up-to-date safety data, coordinate with your obstetric or primary care provider, and help you choose the best treatment approach for your situation.