8 Best Creams for Psoriasis Available Over the Counter in 2025

August 1, 2025

Board-certified dermatologist specializing in eczema and psoriasis, and Chief Medical Officer at Zest Health, Dr. Rachel Day, was consulted by Everyday Health on the best over-the-counter creams (OTC) available for psoriasis.

In addition to her product recommendations, Dr. Day wants readers to know that psoriasis should be treated holistically and OTC creams can play a big part in the overall treatment. She also said that many people with psoriasis may also need medical treatment with a dermatologist.

Dr. Day also told Everyday Health that OTC creams are created equal and the best ones to use for psoriasis include a combination of moisturizing ingredients and gentle exfoliants.

The Skin Deep Summary

Get fast, expert-backed online eczema treatment and virtual dermatology care with Zest. Book a next-day appointment, message your dedicated care team 24/7, and get specialized support.

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Get fast, expert-backed online psoriasis treatment and virtual dermatology care with Zest. Book a next-day appointment, message your dedicated care team 24/7, and get specialized support.

Learn more

FAQs

What is Zest Health?

Zest is a virtual dermatology clinic designed for people living with chronic skin conditions like eczema and psoriasis. We provide individualized care that combines expert treatment with lifestyle support reducing reliance on long-term use of medications for control.

What skin conditions does Zest treat?

Zest Health focuses exclusively on psoriasis and eczema—two of the most common and complex chronic inflammatory skin conditions. Our dermatology providers offer deep expertise and tailor treatment plans to each patient’s unique symptoms, history, and lifestyle. We go beyond symptom relief to identify and address the underlying causes and triggers of flare-ups. Whether you’re newly diagnosed or managing a long-term condition, Zest can serve as a second opinion or works alongside your existing care team.

Who does Zest treat?

Zest is designed for people living with chronic skin conditions like eczema and psoriasis who need ongoing, specialized care. Organizations that partner with Zest gain a way to improve access and outcomes for their members without over reliance on prescription medications. Individuals seeking care for other skin concerns are not a fit for our program today.

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